For many years, public health officials have anticipated the emergence of a highly contagious respiratory virus with pandemic potential. When severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began circulating in late 2019, it was immediately compared with both seasonal and pandemic influenza virus given the common features shared by these viruses. Both SARS-COV-2 and influenza viruses have demonstrated their ease of person-to-person transmission through the respiratory droplet route. The diseases caused by these viruses also share similar clinical presentations, including fever and respiratory symptoms that range from mild forms, such as cough, to severe lung infections. However, coronavirus disease 2019 (COVID-19) has also demonstrated distinct clinical characteristics, such as anosmia and hypogeusia. Although the search for a vaccine and a treatment continues for COVID-19, influenza has become detectable, vaccine preventable, and treatable.