This review article will focus on these neurologic manifestations (with neuroradiologic correlates), which tend to present with more severe signs and symptoms. We have categorized these neurologic manifestations by presumed pathophysiologic processes, especially cerebrovascular disease and inflammatory disease. It should be noted, however, that COVID-19 is a new disease, and all research that is currently available is inherently limited in size, scope, and duration. Therefore, at this point, definitive understanding of disease mechanisms and causal relationships are limited. Furthermore, the underlying pathophysiologic processes maybe concurrent and related, rather than distinct and independent; for example, a marked inflammatory response may be the cause of the observed cerebrovascular disease.