Chest CT for detecting COVID-19: a systematic review and meta-analysis of diagnostic accuracy

The keys to control COVID-19 are early discovery, early isolation, and early treatment. At present, the real-time reverse transcription polymerase chain reaction (RT-PCR) assay remains the standard of reference, but it was reported that false negative RT-PCR was not rare and, in these patients, initial chest CT might present abnormal findings indicating COVID-19. Moreover, shortage of laboratory test kits limited the use of RT-PCR with the spread of the epidemic, especially in regions severely affected by the epidemic. Therefore, some experts suggested that chest CT could be regarded as a diagnosis standard of COVID-19. The guideline of Diagnosis and Treatment of Pneumonitis Caused by 2019-nCoV (trial sixth version) published by the China government recommended chest CT as an effective method to screen suspicious cases. The addition of chest CT for diagnosis of COVID-19 resulted in tens of thousands of clinically diagnosed cases in China which played an important role in controlling epidemic situation in China. Therefore, comprehensive and timely evaluation of the effectiveness of chest CT for COVID-19 diagnosis remains urgent and mandatory. In the present study, we validated the effectiveness of chest CT for COVID-19 diagnosis through a systematical meta-analysis.

Chest CT for detecting COVID-19: a systematic review and meta-analysis of diagnostic accuracy
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