Predicting Disease Severity and Outcome in COVID-19 Patients: A Review of Multiple Biomarkers

While non-specific, acute phase reactants including CRP, ferritin, SAA, and
procalcitonin were reported as sensitive markers of acute COVID-19 disease. Significantly elevated WBC count, marked lymphopenia, decreased CD3, CD4 or CD8 T-lymphocyte counts, high neutrophil count, thrombocytopenia, and markedly elevated inflammatory biomarkers were associated with severe disease and the risk of developing sepsis with rapid progression. Trends observed by serial laboratory measurements during hospitalization including progressive decrease of lymphocyte count, thrombocytopenia, elevated CRP, procalcitonin, increased liver enzymes, decreased renal function, and coagulation derangements were more common in critically ill patient groups and associated with a high incidence of clinical complications.

Predicting Disease Severity and Outcome in COVID-19 Patients: A Review of Multiple Biomarkers
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