Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS-CoV-2

Initial reports from the Severe Acute Respiratory Coronavirus 2 (SARS-CoV 2) pandemic described children as being less susceptible to Coronavirus Disease 2019 (COVID-19) than adults. Subsequently, a severe and novel pediatric disorder termed Multisystem Inflammatory Syndrome in Children (MIS-C) emerged. We report on unique hematologic and immunologic parameters that distinguish between COVID-19 and MIS-C and provide insight into pathophysiology.

Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS-CoV-2
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