Association of Coronavirus Disease (COVID-19) With Large Vessel Occlusion Strokes: A Case-Control Study

COVID-19 most commonly presents with pneumonia like symptoms, including fever, dyspnea, cough, and severe hypoxia. However, the spectrum of clinical manifestations is broader and includes gastrointestinal disease, headache, altered mental status, anosmia, and confusion. Neurologic manifestations of COVID-19 have been described. In one study from China neurologic symptoms were found in as many as 36% of patients admitted to the hospital with COVID-19. Common manifestations include altered mental status, dysarthria, aphasia, and diffuse corticospinal tract signs, many of which may be seen in patients with acute ischemic infarction. Study results have suggested that endothelial injury in the vessel walls is caused by SARS-CoV-2 binding to angiotensin-converting enzyme 2 (ACE-2) receptors. The result is activation of a cytokine cascade that aggravates the vessels and ultimately leads to vascular thrombosis.

Association of Coronavirus Disease (COVID-19) With Large Vessel Occlusion Strokes: A Case-Control Study
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