Multisystem Inflammatory Syndrome in U.S. Children and Adolescents

The coronavirus disease 2019 (Covid19) pandemic has caused catastrophic disease worldwide, although children have been relatively spared. Severe lung involvement with acute respiratory failure is the most common complication of Covid-19 in adults, but many have complications in multiple organs, including the heart. Adults with severe Covid19 typically present during the second week of illness, a time coinciding with declining viral loads and increasing markers of inflammation. These observations suggest that host tissue damage is mediated by dysregulated innate and adaptive immune responses.

Multisystem Inflammatory Syndrome in U.S. Children and Adolescents
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