A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic with millions of human infections. One limitation to the evaluation of potential therapies and vaccines to inhibit SARS-CoV-2
infection and ameliorate disease is the lack of susceptible small animals in large numbers. Commercially available laboratory strains of mice are not readily infected by SARS-CoV-2 because of species-specific differences in their angiotensin-converting enzyme 2 (ACE2) receptors.

A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies
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